I Exchange For Black Technology By Blowing Up The Bully

Chapter 711 A New Breakthrough In Organ Transplantation?

As soon as he finished speaking, all the people in white coats were stunned.

"Boss, you mean... no matter what blood type, the same kind of artificial red blood cells will be used?" Ji Tianhe asked.

"That's right!" Song He nodded, "I don't rule out that some panda blood is not applicable, but common blood types should be universal!"

There was an uproar!

The people in white coats looked surprised, how could this be possible?

Some blood types can be mixed. For example, type O blood can be transfused to any blood type, but only in small amounts. If the amount is too large, problems may arise. Clinically, it is best to use blood of the same type for blood transfusion.

As for the artificial blood project, the boss has long made it clear that the goal is to truly replace human blood in large quantities. It should produce different blood types, but now it is said that it is no longer necessary. Is it universal?

How can this be universal?

Medicine... no longer exists?

"Everyone looks at the first data sheet. It is two enzymes that I extracted from the gastrointestinal tract of mice and conducted a seamless test and analysis." Song He gave a lecture.

"One is deacetylase and the other is galactosaminase, but they are different from the traditional similar enzymes. They are brand-new varieties. I have put the specific changes on the second page, so you can take a closer look later."

"I found that these two enzymes are very picky and only feed on sugars with similar blood cell antigens, so I tried extracting them and using them in the blood. It worked wonders!"

"After these two enzymes are injected into the blood of mice in large amounts at different proportions, they can quickly change the antigens of blood cells throughout the mouse's body and rapidly reduce the agglutination reaction after mixing different blood types. I just made a set, which can reduce it by about 98%. No. If something goes wrong, this change can last for a long time.”

"As long as the contents of the two enzymes are adjusted in different proportions and bundled with the carbonic acid dehydrogenase in our artificial blood, then..."

Lu Chengen understood, "So what you're saying is that you don't need to make red blood cells of different blood types, but you need to make different proportions of enzymes to alleviate adverse reactions after blood transfusion?"

"Yes!" Song He nodded.

The people in white coats breathed a sigh of relief. It turned out to be a play on words. They still needed to create different types of artificial blood. It was just that they changed from creating different red blood cells to creating different enzymes. In fact, it was equivalent to different blood types in disguise.

But having said that, if this method really works, from the perspective of industrial manufacturing, it will really save a lot of trouble. It is similar to frying several dishes with the same process, and in the end, depending on the taste of the guests, different seasonings are sprinkled on each plate. Just pack it.

Seasoning package enzymes can be mass-produced cheaply, which will undoubtedly significantly reduce the cost of artificial blood dishes!

"Everyone is busy now. On the one hand, we are doing mouse experiments, and on the other hand, we can try some human blood experiments." Song He said, "The blood type of mice is different from that of humans. Is this plan feasible? It depends on whether we can find similar enzymes from human intestinal flora."

The people in white coats nodded excitedly. Everyone understood the whole idea. It was nothing more than translating what Song He did to mice to humans. Everyone would still be able to copy the gourd!

This is what scientific research is like. Ideas are the most important, but labor is cheap. Sometimes a lot of work is just to find a wonderful idea. Hundreds of pounds of sweat can be exchanged for a flash of inspiration, and the transaction is worth it!

"I have two questions." Lu Chengen frowned.

"Say it." Song He waved his hand to signal everyone to be quiet.

"For the first question, please refer to the chapter on blood transfusion in the Human Health Edition of Physiology." Lu Chengen said, "The priority for blood transfusion is not to destroy the red blood cells of the blood donor, but after a large amount of blood transfusion, the recipient must also be considered. of red blood cells."

"For example, type O blood has no antigen of its own, but has two antibodies, A and B. Therefore, after blood is transfused to patients with other blood types, it will only cause the destruction of red blood cells of other blood types, but not its own damage. When a small amount of blood is transfused, O Blood type blood is less destructive and cannot be felt, so it can be used for emergency treatment.”

"But if type O blood is transfused too much to other blood types, the destructive power will increase, and large-scale adverse reactions will easily occur. Therefore, type O blood is not used for large-scale cross-blood transfusions clinically, and is only used for emergency treatment."

"Your method of adding enzymes seems to me very similar to type O blood." Lu Chengen looked worried, "Then..."

"It is indeed similar, but there are differences, and it is also a last resort!" Song He said.

"We are doing experiments on mice. What is the cause of blood transfusion problems? It is difficult to control the amount of protein and polysaccharides. There is still a gap between the red blood cells we make and those produced naturally. If we want to create a blood type, there will always be a part of it that secretly Become a different blood type."

"So now we can only use enzymatic methods. Enzymatic methods can stably produce the same blood cells. It can be understood as stably producing type O blood, but it is less angular than type O because we can omit the antigen. In this way, This can greatly reduce the side effects of artificial blood entering the human body!"

"To what specific extent can it be reduced?" Lu Chengen asked.

"I don't know, it depends on the experimental effect." Song He said, "I believe the effect will be very good, as long as we find the right enzyme!"

Lu Chengen nodded, thoughtfully, his expression gradually changed from doubtful at first to belief.

It sounds really feasible!

"What about your second question?" Song He reminded.

"The second question is about clinical application." Lu Chengen said, "Do you know about organ transplantation of different blood types?"

Song He was stunned for a moment, then thought of something, his eyes widened, "Fuck, what do you mean..."

"Yes, I think it is possible." Lu Chengen nodded and smiled, "If it can be done, it will bring the field of organ transplantation into a new era! Assuming that one of the original 200,000 kidneys is successfully matched, what if your enzymatic method If it works, it may be reduced to 30,000 to 40,000 for one successful kidney match, and several times the number of organ transplant patients will be saved!"

"F*ck!" Song He was pleasantly surprised, "I didn't expect this, this is such an unexpected surprise!"

The other team members in the room looked confused and turned their heads left and right. Seeing that the boss and Lu Chengen both looked excited, they became anxious.

"What do you mean, Professor Lu?"

"What do you mean, boss, we didn't understand!"

"Tell me, boss, why does it have anything to do with organ transplantation?"

The scene was noisy, Song He quickly pressed his hand to signal everyone to be quiet.

"It's actually very simple. When performing organ transplantation in clinical practice, the blood type of the organ and the patient must be considered. Only when the blood type is consistent can the organ be transplanted." Song He said.

"For example, if type A lungs are transplanted to a patient with type O blood, once the blood enters the lungs, it will cause a hyperacute rejection reaction. At best, the organ will be wasted, and at worst, the patient will be lost altogether."

"But we can use enzymatic methods to eliminate the rejection caused by different blood types. In the future, blood types can be ignored in organ transplantation, and the success rate of matching will skyrocket several times! Many patients who were originally unsuitable can be matched. On!"

Everyone gasped. Organ transplantation is a difficult technology in medicine, but now there is the possibility of significant improvement?

"Don't rush to be happy yet!" Song He knocked on the test bench, "We just saw hope that the enzymatic method will be successful. If it is really possible, I would like to thank you all for working overtime to verify it! The mouse experiment and the human blood experiment will be carried out as soon as possible!"

"Where do the materials for human blood experiments come from?" Fan Tao asked, "Can everyone donate a little?"